I did one small paper looking at whether the genes that predicted someone having high or low ACE inhibitors made them more or less likely to be hospitalised with COVID. This was because there were some lab results that ACE enzymes were part of how COVID infected cells, and there were concerns that people taking drugs that affected these enzymes might be making themselves more likely to get very ill with COVID. We didn’t find any evidence that people with naturally high levels of ACE inhibitors were getting more or less ill with COVID, so we concluded that it was unlikely that using drugs to increase or decrease the levels of ACE enzymes would impact COVID infections.
This was helpful because it gave doctors more confidence to keep people on their usual medications.
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